Nolvadex a drug that contains a molecule Tamoxifen has been approved by the FDA for prevention and treatment of breast cancer also know as a Selective Estrogen Receptor Modulator (SERM) which acts as a weak estrogen which competes for the estrogen receptor site. Tamoxifen is also known as an Anti-Estrogen / Estrogen-Blocker since it inhibits the activity of regular estrogens.
Tamoxifen just like every other drug has its own list of side effects, so I do not recommend it for use throughout your steroid cycles but rather save this drug for an effective post-cycle-therapy (PCT). Some of the side effects include eye damage, studies have been carried out and reports of cataracts, irreversible damage to the corneal opacities and retina at dosage as low as 20mg per day. I can personally vouch for severe effects to my vision while using Tamoxifen; however they seem to subside a week or two after the discontinuation of this drug.
Gynecomastia is glandular proliferation of the component of the breast which is caused by altered androgens and estrogen balance in which the body’s hormones favor is that of estrogen. This is a common side effect while taking highly androgenic aromatizing steroids without using an aromatizing inhibitor. For Gynecomastia it actually protects you at the receptor site level, however not nearly well enough or we would not see the amount of Gynecomastia cases while using Tamoxifen. Yet in early signs of Gynecomastia such as puffy or itchy nipples I find it’s highly effective and extremely important to initially start with Tamoxifen while you wait for drugs like Arimidex and Letrozole to stabilize in the body. I also find these early signs of Gynecomastia seem to rid in just a few days after the administration of Tamoxifen.
For fertility its results are that of increased sperm density and live spermatozoa in which Tamoxifen bounds itself on the cytosolicER (estrogen receptor) in the hypothalamus (a portion of the brain that contains a number of small nuclei) preventing feedback inhibition by estrogens which results in stimulation of GnRH which is an acronym for Gonadotropin-releasing hormone. It does this by raising Follicle Stimulating Hormone (FSH) which is important for spermatogenesis and Luteinizing Hormone (LH) also known as lutropin, which is responsible for the production and release of testosterone and in women it helps regulate the menstrual cycle and egg production (ovulation). The effects of Tamoxifen are only possible when our androgen levels are low enough to stimulate these hormones, so please refer to our Post-Cycle-Therapy section for the correct timing of when your PCT should be carried out. Tamoxifen also works differently in the way HCG Pregnyl or synthetic Ovidrel (Refer to peptide hormone article on hCG) affects Luteinizing Hormone in that hCG mimics LH where Tamoxifen increase the LH response to Luteinizing-Hormone-Release-Hormone (LHRH) which then increases LH itself. Tamoxifen in general is cycled for a desired dose of 20mg for a cycle duration of 30 days following all Anabolic Steroid cycles, regardless of how mild you may believe the shutdown and suppression might be on your hypothalamic-pituitary-testicular (HPTA) axis
Studies carried out on women who use Nolvadex for fertility have reported an increased average of around 35% in conception. Please just a vital note to our female members; do not use an estrogen birth control while you cycle Tamoxifen. As hormonal birth control (the pill) being an estrogen and Tamoxifen (SERM) being an Anti Estrogen would cause them to clash, so a non-hormonal form of birth control like a condom would be favored here. If you are using a “Progesterone” Depo-Shot then there is no reason for concern, however I would not see the reason for using Depo/Provera as you more than likely going to be holding allot of water depending on your bodies chemistry.